Table 4.

Predicted percentages of paromomycin systemic absorption (% dose) following administration of WR 279,396 to adult subjects on day 20

Day, treatment, and statistic	Dose (g)	CumDosea (g)	AUC0–24 (ng · h/ml)	AUC/Db (h/ml)	Amt abs.c (mg)	% Dose	Accumd
Day 1
Paromomycin
No. of subjects	13	13	13	13
Mean value (SD)	2.1 (1.5)	2.1 (1.5)	2,180 (2,621)	823.5 (815.1)
% CV	69.8	69.8	120.2	99.0
GeoMean value	1.7	1.7	278.7	156.0
WR 279,396
No. of subjects	13	13	13	13
Mean value (SD)	2.6 (1.4)	2.6 (1.4)	975.6 (1,078)	344.3 (309.2)
% CV	54.7	54.7	110.5	89.8
GeoMean value	2.3	2.3	125.7	65.69
Day 20
Paromomycin
No. of subjects	13	13	13	13	13	13	10
Mean value (SD)	3.4 (1.7)	53.3 (21.4)	8,575 (7,268)	2,344 (1,249)	65.2 (48.9)	12.0 (6.26)	6.26 (9.34)
% CV	50.4	40.1	84.8	53.3	75.1	52.0	149.2
GeoMean value	3.0	48.6	6,173	2,070	47.2	10.6	3.21
WR 279,396
No. of subjects	13	13	13	13	13	13	9
Mean value (SD)	3.4 (1.9)	57.8 (25.3)	6,037 (3,956)	1,926 (1,466)	46.1 (28.7)	9.68 (6.05)	4.94 (4.40)
% CV	55.4	43.7	65.5	76.1	62.3	62.5	89.1
GeoMean value	2.8	52.1	2,681	1,022	21.2	4.96	3.82

^aCumDose, cumulative dose over 20 days.

^bAUC/D, AUC_0–24 divided by administered dose of cream.

^cAmt abs., amount of paromomycin systemically absorbed; based upon an adult paromomycin clearance of 7.32 liters/h/1.73 m².

^dAccum, accumulation: (AUC/D for day 20)/(AUC/D for day 1).