Fig 3.

CFU enumeration in the spleens and livers of infected mice treated with eCATH1, rifampin, or a combination of both drugs. Mice were infected with 10⁸ CFU of virulent R. equi via the tail vein. One day postinfection, drugs were subcutaneously injected daily for 7 days. After completion of the therapy, CFU were enumerated in preparations of spleens (A) and livers (B). The results are expressed as log₁₀ CFU per gram of organ. Values are means ± SD for 5 animals in each group at each time point from two independent experiments. Significance: *, P < 0.05 (eCATH1 or rifampin versus no drug), and °, P < 0.05 (eCATH1 plus rifampin versus eCATH1 or rifampin). ●, no drug; ■, eCATH1, 1 mg/kg; ▲, rifampin, 10 mg/kg; ▼, eCATH1 plus rifampin.