Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Pharmacokinetic parameters for compound 2 in male NMRI mice
| Parameter (units) | Result after treatment |
|
|---|---|---|
| 1 mg/kg i.v. | 5 mg/kg orally | |
| C0 or Cmax (ng/ml) | 1,559 | 782 |
| Tmax (h) | 0.5 | |
| AUC(0–t) (ng · h/ml) | 503 | 1,281 |
| AUC(0–∞) (ng · h/ml) | 519 | 1,566 |
| Cl (liters/h/kg) | 1.93 | |
| Vss (liters/kg) | 2.23 | |
| t1/2 (h) | 2.38 | 4.15 |
| F (%) | 60 | |
