Table 4.

Susceptibility to alternative antimicrobials in relation to trimethoprim-sulfamethoxazole (TMP-SMZ) phenotype

Resistance groupa	ST131 status	Alternative agentb	Phenotypec	No. (%) of isolates with phenotype		P valued
				TMP-SMZ susceptible	TMP-SMZ resistant
FQ-S, ESC-S	ST131	Azithromycin	S	8/12 (75)	1/8 (13)	0.03
		Azithromycin	S or I	10/12 (83)	1/8 (13)	0.005
	Non-ST131	Azithromycin	S	16/16 (100)	2/4 (50)	0.03
		Doxycycline	S	14/16 (88)	1/4 (25)	0.03
FQ-R, ESC-S	ST131	Azithromycin	S	11/12 (92)	1/8 (13)	0.001
		Doxycycline	S	12/12 (100)	3/8 (38)	0.004
	Non-ST131	Doxycycline	S	7/10 (70)	0/10 (0)	0.003
		Doxycycline	S or I	9/10 (90)	2/10 (20)	0.005
		Minocycline	S	8/10 (80)	1/10 (10)	0.005
		Minocycline	S or I	10/10 (100)	5/10 (50)	0.03
FQ-R, ESC-R	ST131	Azithromycin	S	4/6 (67)	2/14 (14)	0.04
		Azithromycin	S or I	6/6 (100)	4/14 (29)	0.01

^aFQ-S and FQ-R, fluoroquinolone susceptible and resistant; ESC-S and ESC-R, extended-spectrum-cephalosporin susceptible and resistant.

^bOnly drugs that yielded P values of <0.05 in at least one comparison are shown.

^cS, susceptible; I, intermediate.

^dDetermined by Fisher's exact test.