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Infection of mice with the pneumococcal phosphodiesterase mutants. Approximately 5 × 106 CFU of the WT, Δpde1, Δpde2, or Δpde1 Δpde2 strain was inoculated intranasally in 50 μl PBS, and the mice were subsequently monitored for 9 days. The indicated P values are the statistical results for each mutant compared to the WT and analyzed by the log-rank (Mantel-Cox) test using Prism 5.0a (GraphPad Software).
