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PMT deamidates and activates heterotrimeric Gα proteins. The activation of diverse G protein-coupled receptor signal transduction pathways by PMT leads to several phenotypes that are disruptive to the host. PMT activates Gαi, Gαq/11, and Gα12/13 but not Gαs. PMT also triggers the release of Gβγ from the heterotrimeric complex, which leads to activation of the phosphoinositide-3-kinase (PI3K) pathway.
