Table 4.
Nonsynonymous mutations in RpoC in the region around amino acid 500 (amino acids 431 to 527), previously implicated to possibly compensate for RpoB mutations
| Strain(s)a | Gene | Nonsynonymous mutation | Lineage (cluster) |
|---|---|---|---|
| 0316 | rpoC | Val431Met | X |
| 0301 | rpoC | Gly433Ser | X |
| 0902 | rpoC | Val483Ala | H |
| 0304 | rpoC | Val483Gly | LAM (c2) |
| 0303 | rpoC | Val486Glu | H |
| 0203 | rpoC | Ile491Thr | LAM (none) |
| 0402 | rpoC | Gly519Val | LAM (noneb) |
| 0909, 0207, 0314, 0607, 0609, 0803, 0904, 0601 | rpoC | Leu527Val | LAM (c1c) |
a
These are all MDR strains. No mutations were found in this region of RpoB in any of the drug-susceptible strains.
b
Associated with KZN strains.
c
A subcluster (single branch) consisting of 8 of 29 isolates in the LAM9-c1 cluster.