Fig. 3.

Blood glucose level and β-cells of Atg7^Δβ-cell-ob/ob mice. (A, B) Apoptotic β-cell number (A) and β-cell mass (B) are shown. (C) Fasting blood glucose levels were determined in Atg7^F/F-ob/w (n=7), Atg7^Δβ-cell-ob/w (n=6), Atg7^F/F-ob/ob (n=5), and Atg7^Δβ-cell-ob/ob mice (n=4). (D) Intraperitoneal glucose tolerance test was performed, and the results from Atg7^Δβ-cell-ob/ob mice were compared with those of other types of mice (n=4, each group). Atg, autophagy-related gene. ^aP<0.05; ^bP<0.01; ^cP<0.001. Adapted from Quan W, et al. Diabetologia 2012;55:392-403, with permission from Springer Science+Business Media [15].