Table 1.
M. avium subsp. paratuberculosis proteins implicated in invasion
| Locus tag | Protein | Host cell type | Evidence | Reference |
|---|---|---|---|---|
| MAP_2121c | Major membrane protein I | MDBK | Antibody against protein blocks invasion | 51 |
| MAP_3464 | NADH-dependent oxidoreductase | MDBK | Gene knockout lowers invasion, and complementation restores invasion | 23 |
| MAP_3212 | NADH-ubiquinone oxidoreductase | MDBK | Gene knockout lowers invasion | 23 |
| MAP_3607 | Mycobacterial cell entry (Mce1D) | MDBK | Gene knockout lowers invasion | 23 |
| MAP_0941 | Arginine deaminase (ArcA) | MDBK | Gene knockout lowers invasion | 23 |
| MAP_2808 | Potassium transporter (TrkA) | MDBK | Gene knockout lowers invasion | 23 |
| MAP_2938c | Isoprenoid biosynthesis | Calf intestine | Gene knockout lowers invasion | 28 |
| MAP_1242 | Lipotripeptide biosynthesis (PstA) | Calf intestine | Gene knockout lowers invasion | 55 |
| MAP_0482 | Transcriptional regulator (LuxR) | MDBK | Gene overexpression increases invasion | 38 |
| MAP_3985c | Hypothetical protein | MDBK | Secreted protein. Binds Cdc42 and activates it | 23 |