Fig 1.

(A) Cartoon schematic illustrating the Rpd3L, Rpd3S, and Rpd3μ complexes. (B) The domain architecture of Snt2 and Ecm5 reveals multiple, putative chromatin and DNA binding domains. (C) Rpd3μ localizes to two distinct types of promoters. Upon oxidative stress, all three members of the Rpd3μ complex are recruited to oxidative stress response promoters, though Rpd3 recruitment is not dependent on Snt2 or Ecm5. The superenriched promoters are constitutively bound by Snt2 and Ecm5, and recruitment of Rpd3 is dependent upon both Snt2 and Ecm5. Recent work suggests that Ecm5 may bind histone H3 lysine 36 trimethylation (red triangles).