Fig 8.

Prdm4 mutant mice are viable and fertile. (A) Intercross matings of heterozygous Prdm4^+/Δ^ZF and Prdm4^+/LacZ animals generate Mendelian numbers of wild-type and heterozygous and homozygous mutant progeny. (B) Germ cell maturation and gonadal development are unperturbed in adult male and female Prdm4 mutant mice. Hematoxylin- and eosin-stained sections through the ovaries and testes of wild-type and mutant littermates fail to reveal defects in germ cell maturation. Abbreviations: ST, seminiferous tubules; CL, corpus luteum; II, secondary follicle; III, tertiary follicle; Oo, oocyte; GC, granulosa cells.