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. 2013 Nov;33(21):4140–4151. doi: 10.1128/MCB.00410-13

Fig 7.

Fig 7

(A) Multipoint binding of SLP-76 to ADAP induces oligomerization of SLP-76 upon TCR stimulation. The binding of ADAP favors SLP-76 clustering and interferes with the binding of HPK1. (B) Separate models for oligomerization of LAT and SLP-76/LAT complexes. (1) Interactions between bivalent LAT and Grb2/Sos complexes can induce oligomerization of LAT into chains. However, if LAT binds 3 Grb2/Sos complexes, the oligomerization potential increases. (Adapted from reference 52 with permission.) (2) Association of the Gads/SLP-76 complex with LAT reduces the number of Grb2 binding sites to two, allowing only the assembly of chains. Multipoint binding of SLP-76 to ADAP oligomerizes SLP-76 and increases the oligomerization potential of LAT complexes.