Fig 15.

Overexpression of VEGFR2 reversed Cdc42 deletion-induced EC apoptosis but not migration defects. (A) Lysates from primary cultured mouse ECs infected with Ad-LacZ, Ad-Cre, or Ad-Cre plus Ad-VEGFR2 were analyzed by Western blotting using different antibodies as indicated. (B) The intensities of bands for cleaved caspase 3 and VEGFR2 were quantitatively analyzed. *, P < 0.05. (C) Cultured primary mouse ECs were infected with Ad-LacZ, Ad-Cre, or Ad-Cre plus Ad-VEGFR2 and were subjected to Boyden chamber analysis following the response to VEGF (1 ng/ml). *, P < 0.05.