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Deletion of Cdc42 induced massive apoptosis during embryogenesis. (A and B) Hematoxylin and eosin staining analyses were performed on E9.5 control (A) and CEKO (B) embryos. Bars, 200 μm. (C and D) Higher-magnification microphotographs of control (C) and CEKO (D) embryos. Arrowheads (D) indicate massive pyknotic and fragmented nuclei. Bars, 25 μm.
