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. Author manuscript; available in PMC: 2014 Oct 1.
Published in final edited form as: Bioorg Med Chem. 2013 Aug 2;21(19):10.1016/j.bmc.2013.07.046. doi: 10.1016/j.bmc.2013.07.046

Figure 3.

Figure 3

PET studies of specificity and selectivity of [11C]3. (a) Comparison of [11C]3 distribution in rat brain at the time interval 2-15 min in a control study, after blocking of mGlu4 with 4.HCl (10 mg/kg i.p. 30 min before [11C]3 injection) and after blocking of mGlu5 with MTEP (5 mg/kg i.v. 2 min before [11C]3). Coronal images are at the striatal and hippocampal level while axial and sagittal views at the midstriatal level. (b) The uptake of [11C]3 was reduced by 23-28% in all brain areas with 4.HCl while MTEP induced blocking was minor.