Figure 1.
Electron Micrograph of a glomerulus from an 11-years-old boy with Fabry disease. The patient had normal GFR and a urine protein/creatinine ratio of about 40 mg/g at biopsy. There are abundant GL-3 inclusions (long black arrows) in podocytes (PC). Similar inclusions are found in endothelial cells (white arrow) and mesangial cells (spiral arrow). Short black arrows show widened foot processes over a capillary (Cap) loop. Arrowheads show loss of fenestration in an endothelial cell. Magnification: 35,000 x.
