Figure 6. In vivo protective effect of A. muciniphila-derived EV on the development of 2% DSS-induced colitis.

For all figures, mice (each group = 5) were ingested by A. muciniphila (Bacteria, 5.0×10⁸) or A. muciniphila-derived EV (Am EV, 100 µg), concomitantly with water or 2% DSS. (A) Body weight changes (%). (B) Colon lengths. **, p<0.01. (C) Changes of disease activity index, reflected by body weight, colon length, diarrhea, and stool blood. (D) Histology (upper panel) and histological activity index (lower panel) of colon. Arrows indicate injury area, and histological activity index was measured by epithelial barrier disruption and infiltration depth of inflammatory cells. *. p<0.05 vs. the DSS and DSS+Bacteria groups.