Figure 4. Influence of treatment with a single intraperitoneal dose of 0.14/kg vardenafil (vard) on the separate components of chloride transport in wild-type mice (WT), in mice heterozygous (HTZ) and homozygous (CF) for the F508del mutation.

Responses of the rectal mucosa to perfusion with chloride-free solution containing barium and amiloride and responses of the rectal mucosa to the further addition of forskolin are shown as means (± SEM) for 5–11 animals per group. P values denote levels of significance of between-group comparisons for the same component of the chloride transport.