Table 3. Correlations between % change in arachidonic acid (ARA, 20:4n6), eicosapentaenoic acid (EPA, 20:5n3) and docosahexaenoic acid (DHA, 22:6n3), their oxylipin products, and baseline values at p ≤ 0.05.
| Variable X | Variable Y | Rsquare | P-value |
|---|---|---|---|
| % Change CE20:4n6 | % Change PGF2α | -0.501 | 0.015 |
| % Change PE20:4n6 | % Change PGD2 | 0.378 | 0.033 |
| % Change PC20:4n6 | % Change PGF2α | -0.715 | 0.001 |
| % Change PE20:4n6 | % Change TXB2 | 0.469 | 0.014 |
| % Change PE20:4n6 | % Change 12-HEPE | 0.402 | 0.027 |
| % Change PE20:4n6 | % Change CE22:6n3 | 0.506 | 0.021 |
| % Change FFA20:4n6 | % Change 5-HETE | 0.561 | 0.005 |
| % Change PE20:4n6 | % Change 8-HETE | 0.340 | 0.047 |
| % Change TG20:4n6 | % Change 9-HETE | 0.522 | 0.008 |
| % Change PE20:4n6 | % Change 12-HETE | 0.427 | 0.021 |
| % Change FFA20:4n6 | % Change 15(S)-HETrE | 0.383 | 0.032 |
| % Change FFA20:4n6 | % Change 5-HEPE | 0.758 | 0.0002 |
| Body Weight (kg) | % Change 8,9-DiHETE | -0.446 | 0.018 |
| Body Weight (kg) | % Change 17,18-DiHETE | -0.521 | 0.012a |
| Body Weight (kg) | % Change 10,11-DiHDPE | -0.477 | 0.013 |
| Body Weight (kg) | % Change 15-HEPE | -0.408 | 0.025 |
| Body Weight (kg) | % Change 17-HDoHE | -0.353 | 0.042 |
| Body Weight (kg) | % Change Medium VLDL Particles | 0.394 | 0.039 |
| Body Weight (kg) | % Change HDL Size (nm) | -0.326 | 0.052 |
| Body Weight (kg) | % Change DG22:6n3 | -0.525 | 0.018 |
| Body Weight (kg) | % Change FFA18:3n6 | -0.414 | 0.033 |
| Body Weight (kg) | % Change FFA20:5n3 | -0.519 | 0.008 |
| Body Weight (kg) | % Change FFA22:6n3 | -0.406 | 0.026 |
| Body Weight (kg) | % Change PE22:0 | 0.476 | 0.027 |
| Body Weight (kg) | % Change TG22:0 | -0.484 | 0.025 |
| Body Weight (kg) | Baseline PE EPA% | 0.363 | 0.038 |
| Body Weight (kg) | Baseline PE EPA/ARA | 0.325 | 0.053 |
| BMI | Baseline PC ARA% | 0.431 | 0.020 |
| BMI | Baseline PE EPA% | 0.496 | 0.011 |
| BMI | Baseline PE EPA/ARA | 0.461 | 0.015 |
| % Change FFA20:5n3 | % Change 8,9-DiHETE | 0.439 | 0.019 |
| % Change FFA20:5n3 | % Change 11,12-DiHETE | 0.409 | 0.025 |
| % Change DG20:5n3 | % Change 14,15-DiHETE | 0.691 | 0.003 |
| % Change TG20:5n3 | % Change 17,18-DiHETE | 0.891 | <0.0001b |
| % Change FFA20:5n3 | % Change 17,18-DiHETE | 0.344 | 0.045 |
| % Change CE20:5n3 | % Change 17,18-DiHETE | 0.860 | <0.0001b |
| % Change FFA20:5n3 | % Change 5-HEPE | 0.643 | 0.002 |
| % Change CE20:5n3 | % Change 15-HEPE | 0.466 | 0.021 |
| % Change FFA20:5n3 | % Change 15-HEPE | 0.666 | 0.001 |
| % Change PC20:5n3 | % Change 15-HEPE | 0.452 | 0.017 |
| % Change FFA22:6n3 | % Change 10(11)-EpDPE | 0.468 | 0.014 |
| % Change FFA22:6n3 | % Change 10,11-DiHDPE | 0.820 | 0.0001 |
| % Change FFA22:6n3 | % Change 13,14-DiHDPE | 0.488 | 0.011 |
| % Change FFA22:6n3 | % Change 16,17-DiHDPE | 0.544 | 0.006 |
| % Change TG22:6n3 | % Change 19,20-DiHDPE | 0.360 | 0.039 |
| % Change FFA22:6n3 | % Change 19,20-DiHDPE | 0.432 | 0.020 |
| % Change FFA22:6n3 | % Change 17-HDoHE | 0.690 | 0.001 |
| % Change TG22:6n3 | % Change 17-HDoHE | 0.467 | 0.014 |
| Baseline PC ARA% | % Change 5-HEPE | -0.350 | 0.043 |
| Baseline PC ARA% | % Change 15-HEPE | -0.399 | 0.028 |
| Baseline PE ARA% | % Change PE22:6n3 | -0.711 | 0.001c |
| Baseline PC EPA% | % Change 5-HEPE | -0.335 | 0.049 |
| Baseline PC EPA% | % Change 12-HEPE | -0.344 | 0.045 |
| Baseline PC EPA% | % Change 15-HEPE | -0.412 | 0.024 |
| Baseline Medium VLDL Particles | % Change DG22:6n3 | 0.416 | 0.044 |
| Baseline LDL Size | % Change PC22:6n3 | -0.372 | 0.035 |
| Baseline HDL Size | % Change PC22:6n3 | -0.327 | 0.052 |
a Outlier removed: Subject 214
b Subject 214 was considered a hyperresponder and was kept in the analysis, rather than being excluded as an outlier
c Outlier removed: Subject 220