Table 1. PRC target genes are overrepresented in the renal cancer methylome.

	Total hyper-methylated genes	All 3 marks	Frequency (%)	p-value	1 or more marks	Frequency (%)	p-value
All RCC	292	24	8.2	0.0003	58	19.9	<0.0001
ccRCC	190	27	14.2	<0.0001	55	28.9	<0.0001
pRCC	88	13	14.8	<0.0001	25	28.4	<0.0001
chrRCC	43	7	16.3	0.0002	10	23.2	0.0051
Oncocytoma	109	11	10.1	0.0023	33	30.3	<0.0001

Proportion of PRC target genes among genes hypermethylated in renal cancer compared to ∼4% with 3 marks or 9.5% with 1 or more marks in human ES cells from Lee et al 2006 [48].