Figure 1. Mechanical and thermal nociceptive sensitivity for mice fed high versus low methyl donor diets in the perinatal period.

In panels A and B the mechanical and thermal sensitivity are displayed for male offspring. Panels C and D the mechanical and thermal sensitivity are displayed for female offspring. Values are displayed as the mean ± SEM. n = 14/group. M, male; F, female. *p<0.05 or **p<0.01 versus low methyl diet treatment.