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. Author manuscript; available in PMC: 2014 Feb 1.
Published in final edited form as: Nature. 2013 Jul 24;500(7460):77–80. doi: 10.1038/nature12403

Figure 3. Disruption of Wnt signaling via RNAi rescues regeneration in Reg− tissues.

Figure 3

a-c, Posterior fragments 14 days after amputation in Reg− regions of control(RNAi), Pf-β-catenin1(RNAi), and APC(RNAi) animals. Dashed lines indicate amputation planes; white arrows indicate eyespots; black arrowheads indicate gut branches indicative of posterior fate. d–g, Nervous system in uncut and Reg− body regions of control(RNAi), Pf-β-catenin1(RNAi), and APC(RNAi) animals 28 days after amputation. Anterior is to the left. Scale bars, 250 µm. h, Relative transcript levels in Reg− tissue from Pf-β-catenin1(RNAi), Pf-APC(RNAi), and control(RNAi) animals 48 hours after amputation. Significant differences between control and experimental samples based on p-values (< 0.05) from two-tailed unpaired t-test are shown. (*, Pf-β-catenin1(RNAi) versus control(RNAi); **, Pf-APC(RNAi) versus control(RNAi)). Error bars represent standard deviations.