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Epidemiology
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Geographical distribution (climate)
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Worldwide |
Tropics (hot, humid areas) |
Deserts of Africa and Saudi Arabia (hot, dry areas) |
Central and South America (hot, humid areas) |
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Age group (peak incidence)
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Adults (18–30) |
Children (2–10) |
Children (2–10) |
Adults (15–50) |
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Transmission
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Sexual and congenital |
Skin-to-skin contact |
Mouth-to-mouth or utensils |
Skin-to-skin contact |
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Clinical characteristics
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Initial lesion (location)
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Common (genitals) |
Common (lower extremities) |
Rare (oral mucosa) |
Common (extremities) |
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Dissemination
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Widespread and systemic |
Widespread to skin and bone |
Limited to intertriginous areas and facial bone |
Limited only to skin |
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Late complications without treatment (%)
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Gummas (10%), neurological (10%), cardiovascular (10–15%) |
Destructive lesions of skin and bones (10%) |
Destruction of nose/palate |
Local skin hypo- achromia |
