Table 1. Molecular characteristics of Schistosoma mansoni CD59-like proteins.
| Namea | S. mansoni v5 IDb | pI/Mwc (kDa) | Orthologd Organism (% id) | Primary structure analysise | Locationf Expression | ||
| Signal Peptide | Domain | GPI anchor | |||||
| SmCD59.1 | Smp_019350 | 8.11/11.0 | Ly-6 Sarcophilus harrisii (34%) | x | uPAR/Ly6/CD59/snake toxin | x | Tegument1 ↑Day 3 Sch2 |
| SmCD59.2 | Smp_105220 | 8.33/12.1 | Ly-6D Macaca mulatta (33%) | x | uPAR/Ly6/CD59/snake toxin | x** | Tegument1 ↑Day 3 Sch2 , 3 |
| SmCD59.3 | Smp_081900.2 | 8.47/11.4 | CD59 Myotis davidii (30%) | x | x** | ↑ Day 3 Sch2 | |
| SmCD59.4 | Smp_166340 | 8.65/11.5 | Ly-6 Desmodus rotundus (34%) | x | x** | Tegument4 ↑Day 3 Sch2 | |
| SmCD59.5 | Smp_081920 | 8.66/11.6 | CD59 Myotis davidii (29%) | x | uPAR/Ly6/CD59/snake toxin | x** | Tegument4 ↑Day 3 Sch2 |
| SmCD59.6 | Smp_166350 | 9.00/11.5 | CD59 Canis lupus familiaris (27%) | x | uPAR/Ly6/CD59/snake toxin | x** | |
| SmCD59.7 | Smp_125250 | 8.95/11.4 | Ly-6D Saimiri boliviensis (24%) | x* | x** | ||
a
Proposed gene names (accession numbers of cloned cDNAs).
b
Schisto GeneDB version 5 systematic ID.
c
Molecular weight and isoelectric point.
d
BLASTx analysis for identification of the closest ortholog in GeneBank; ortholog protein, organism, identity.
e
SMART predicts the presence of domains in the protein sequence.
f
Location of the protein in proteomic studies and up regulated stages by microarray analysis;
(1)
Castro-Borges et al., 2011;
(2)
Parker-Manuel et al., 2011;
(3)
Farias et al., 2010;
(4)
Wilson, 2012.
*
Signal peptide prediction with SignalP 4.1 server (D-scores above 0.4 but below 0.5).
**
GPI Prediction Server (Version 3.0) bellows the cut-off.