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. 2013 Oct 29;8(10):e78197. doi: 10.1371/journal.pone.0078197

Figure 3. Co-regulated FFLsin human cancers.

Figure 3

(A) Three types of 3-vertex FFLs found in human cancers. According to the relationship between the miRNA and TF, the mixed FFLs found in human cancers were classified as the TF-FFL (the TF directly regulates the miRNA and target gene while the miRNA also regulates the target gene), miRNA-FFL (the miRNA directly regulates the TF and target gene while the TF also regulates the target gene) or composite-FFL (the TF and the miRNA regulate each other while they also regulate the same target gene). (B) Common TF-FFLs found in both pan-cancer and prostate cancer datasets. Red circles indicate target genes; blue triangles and orange squares indicate TFs and miRNAs.