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. 2013 Oct 29;8(10):e77870. doi: 10.1371/journal.pone.0077870

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© 2013 Fry et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

PMC Copyright notice

A. The Flag-Dmp1 cDNA (BamHI fragment) was recovered from the pFLEX1-Dmp1 vector and was cloned into the HindIII site of the transgenic vector with MMTV promoter (MMTV-SV40-BSSK). B. Whole mammary gland mounts from 12-week-old nulliparous MDTG (strain 79) and wild-type mice. Scale bars show 2 mm. C. Photomicrographs of nulliparous and multi-parous female mammary glands (MMG) from wild-type and strain 76 MMTV-Flag-Dmp1 (MDTG) mice (12-week-old). Wild-type mammary glands were well-dilated with milk production, which became more prominent after getting pregnant. MDTG mammary glands, on the other hand remained small, unopened with little milk production. These mammary glands did not open well with very low milk production even after getting pregnant, making it difficult to feed their pups. The scale bars show 100 µm.