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. 2013 Oct 29;8(10):e77934. doi: 10.1371/journal.pone.0077934

Figure 2. MDL-12,330A, but not SQ 22536, produces prolonged APDs.

Figure 2

Pancreatic beta cells were seeded on glass coverslips and cultured in culture dish for 24-clamp experiments. Artificial APs were elicited by applying 4 ms, 150 pA current injections in perforated whole-cell configuration and were recorded before and 2 min after application of reagents in the same cell. Representative action potential waveforms and summary of mean APDs were shown for cells treated with MDL-12,330A (MDL, 10 µM, n = 6), SQ 22536 (SQ, 10 µM, n = 7) or H89 (1 µM n = 7) at 11.1 mM glucose (Ctrl) conditions. **p<0.01.