Table 1. Clinical features of key member of family AD-FDC1 and AD-FDC27.
| Family and Pedigree ID | Sex | Age at enroll-ment | Follow-up (years) | Symptoms at enrollment | Arrhythmia | NYHA | ECG | LVEDD (cm) | FS% | LVEF% | Outcome |
| AD-FDC1 | |||||||||||
| III:3 | M | 94 | 4 | DOE | PVC | 2 | Incomplete LBBB | N/A | N/A | N/A | CHF death |
| lll:6 | F | 82 | 11 | None | PVC | 1 | Incomplete LBBB | 6 | 32 | 62 | NYHA 2–3, LVEDD 6.4 cm, LVEF 37%, CHF death |
| III:8 | M | 67 | 6 | Shortness of breath | Frequent PVC | 2 | AF, LBBB | 6.2 | 15 | 20 | NYHA 3, CHF death |
| lV:2 | M | 69 | 15 | DOE, orthopnea | AF | 2–3 | AF | 6.3 | 13 | 35 | NYHA 3 |
| lV:4 | M | 46 | 7 | Fatigue | NSVT | 2 | Normal | 6 | 13 | 42 | NYHA 1, LVEF 51% |
| lV:6 | F | 35 | 22 | DOE, PND | NSVT | 3 | PVC, LAFB | 7.1 | 6 | 15 | NYHA 1, LVEF 46% |
| lV:7 | M | 33 | 25 | Abnormal X-ray | NSVT | 1 | 1st degreeAVB, LAFB | 8.7 | 11 | 17 | NYHA 1, LVEF 40%, NSVT |
| lV:13 | M | 52 | 14 | DOE, palpitations | NSVT | 2 | ST changes | 6.9 | 25 | 43 | NYHA 3, LVEF 27%, CHF death |
| lV:14 | M | 45 | 20 | DOE | Frequent PVC | 1 | PVC | 7 | 21 | 41 | NYHA 2, LVEF 47%, Frequent PVC |
| lV:16 | M | 42 | 7 | None | None | 1 | Normal | 6.4 | 17 | 40 | NYHA 2, LVEF 36% |
| V:3 | M | 1 | 21 | None | None | 1 | Normal | N/A | 28 | 76 | NYHA 1, LVEF 44% |
| V:4 | F | 4 | 21 | None | None | 1 | Normal | 4.1 | 29 | 68 | NYHA 1,LV dilatation |
| AD-FDC27 | |||||||||||
| II:6 | M | 54 | 8 | None | None | 1 | LAFB | 6.4 | 23 | 54 | SD |
| II:8 | M | 57 | 11 | DOE | SSS, PM | 1 | PM | 7.1 | N/A | 29 | NYHA 2 |
| II:11 | M | 35 | 18 | DOE | None | 1 | Normal | 6.9 | 17 | 16 | NYHA 4, CHF death |
| III:7 | M | 8 | 15 | None | None | 1 | Normal | 4 | 30 | 60 | Cardiac arrest |
| III:8 | F | 21 | 23 | Syncope | N/A | 1 | Normal | 4.7 | N/A | 48 | Death (accident) |
| III:9 | F | 25 | 15 | Palpitations, syncope | None | 1 | RBBB | 3.8 | 37 | Normal | DCM, LBBB |
NYHA - New York Heart Association class; ECG - Electrocardiogram; LVEDD - left ventricular end-diastolic diameter; LVEF - left ventricular ejection fraction; FS - fractional shortening; DOE - Dyspnea on exertion, PND - Paroxysmal nocturnal dyspnea, DCM - Dilated cardiomyopathy, PVC - Premature ventricular contractions, LBBB - Left bundle branch block, CHF - Congestive heart failure, SD - Sudden death, NSVT - Non-sustained ventricular tachycardia, PM - Pace maker, RBBB - Right bundle branch block, AF - Atrial fibrillation, AVB - 1st degree atrio-ventricular block, LAFB - Left anterior fascicular block, SSS - sick sinus syndrome.