Table 2. Distribution of psychiatric disorders across sex-specific quintiles of SUA.
| SUA (mean, µmol/L) | Q1 224 | Q2 273 | Q3 306 | Q4 343 | Q5 422 | P-trend |
| N(%) | N(%) | N(%) | N(%) | N(%) | (Test statistic) | |
| Lifetime pyschiatric disorders | ||||||
| MDD | 348(47.2) | 323(45.4) | 296(40.8) | 259(40.1) | 251(42.5) | 0.012(−2.51) * |
| Combined MDD | 45(6.1) | 44(6.2) | 46(6.3) | 33(5.1) | 35(5.9) | 0.624(−0.49) |
| Atypical MDD | 46(6.2) | 45(6.3) | 39(5.4) | 44(6.8) | 40(6.8) | 0.623(0.49) |
| Melancholic MDD | 104(14.1) | 94(13.2) | 76(10.5) | 64(9.9) | 70(11.9) | 0.038(−2.07) |
| Unspecified MDD | 153(20.7) | 140(19.7) | 135(18.6) | 118(18.3) | 106(18.0) | 0.144(−1.46) |
| Any anxiety disorder | 162(22.0) | 126(17.9) | 130(18.0) | 102(15.9) | 103(17.6) | 0.015(−2.43) * |
| GAD | 15(2.0) | 16(2.3) | 14(1.9) | 16(2.5) | 17(2.9) | 0.316(1.00) |
| Panic disorder | 24(3.3) | 17(2.4) | 30(4.2) | 26(4.0) | 14(2.4) | 0.965(0.04) |
| Agoraphobia | 26(3.5) | 26(3.7) | 34(4.7) | 29(4.5) | 20(3.4) | 0.735(0.34) |
| Social phobia | 126(17.1) | 84(11.9) | 84(11.7) | 55(8.6) | 70(11.9) | <0.001(−3.62)* |
| Current psychiatric disorders | ||||||
| MDD | 163(22.1) | 126(17.7) | 130(17.9) | 117(18.1) | 121(20.5) | 0.469(−0.72) |
| Combined MDD | 24(3.3) | 21(3.0) | 23(3.2) | 14(2.2) | 24(4.1) | 0.764(0.30) |
| Atypical MDD | 20(2.7) | 22(3.1) | 16(2.2) | 18(2.8) | 21(3.6) | 0.540(0.61) |
| Melancholic MDD | 55(7.5) | 43(6.0) | 38(5.2) | 34(5.3) | 27(4.6) | 0.020(−2.32) |
| Unspecified MDD | 64(8.7) | 40(5.6) | 53(7.3) | 51(7.9) | 49(8.3) | 0.700(0.38) |
| Any anxiety disorder | 97(13.1) | 71(10.0) | 78(10.8) | 50(7.7) | 54(9.2) | 0.005(−2.83)* |
| GAD | 0(0.0) | 0(0.0) | 0(0.0) | 0(0.0) | 0(0.0) | NA |
| Panic disorder | 0(0.0) | 1(0.1) | 0(0.0) | 0(0.0) | 0(0.0) | NA |
| Agoraphobia | 16(2.2) | 17(2.4) | 23(3.2) | 18(2.8) | 10(1.7) | 0.869(−0.17) |
| Social phobia | 85(11.5) | 55(7.7) | 59(8.1) | 34(5.3) | 45(7.6) | 0.001(−3.21)* |
MDD = major depressive disorder; GAD = generalized anxiety disorder; and SUA = serum uric acid.
*
P-value <0.05 for quadratic trend tested by a crude logistic model which included a quadratic term (SUA squared) for continuous value of SUA.