Table 4. Crude and adjusted logistic regression analysis of SLC2A9 rs6855911 and psychiatric disorders according to sex.

		Men		Women
		OR(95% CI)	P-value	OR(95% CI)	P-value	Pinteraction
Lifetime pyschiatric disorders
Any anxiety disorder	Unadjusted	1.38(1.05–1.80)	0.019	0.94(0.78–1.14)	0.525
	Adjusted	1.40(1.07–1.84)	0.015	0.97(0.80–1.17)	0.728	0.026
GAD	Unadjusted	1.22(0.58–2.57)	0.601	0.94(0.58–1.51)	0.797
	Adjusted	1.22(0.57–2.62)	0.602	0.94(0.58–1.52)	0.793	0.520
Panic disorder	Unadjusted	1.57(0.76–3.26)	0.225	0.80(0.55–1.15)	0.224
	Adjusted	1.50(0.72–3.14)	0.277	0.82(0.56–1.19)	0.298	0.128
Agoraphobia	Unadjusted	1.50(0.77–2.92)	0.230	1.00(0.71–1.42)	0.979
	Adjusted	1.61(0.82–3.18)	0.168	1.03(0.72–1.47)	0.865	0.287
Social phobia	Unadjusted	1.43(1.05–1.96)	0.025	0.93(0.75–1.17)	0.559
	Adjusted	1.44(1.05–1.99)	0.023	0.96(0.76–1.21)	0.720	0.033
Current psychiatric disorders
Any anxiety disorder	Unadjusted	1.42(1.00–2.03)	0.053	0.82(0.65–1.04)	0.097
	Adjusted	1.42(0.99–2.03)	0.055	0.84(0.66–1.06)	0.140	0.014
Agoraphobia	Unadjusted	1.15(0.54–2.45)	0.713	0.84(0.54–1.29)	0.421
	Adjusted	1.19(0.56–2.57)	0.649	0.85(0.55–1.32)	0.477	0.466
Social phobia	Unadjusted	1.51(1.02–2.25)	0.042	0.82(0.63–1.06)	0.124
	Adjusted	1.50(1.00–2.23)	0.049	0.83(0.64–1.09)	0.184	0.015

GAD = generalized anxiety disorder.

ORs represent the effect of SLC2A9 rs6855911 used as a continuous score of 0, 1 and 2 corresponding to GG, AG and AA genotype respectively with AA being the genotype associated with elevated levels of serum uric acid.

Adjusted for age, sex, socio-economic status, alcohol consumption, smoking, diabetes, hypertension, GFR (calculated according to Modification in Diet in Renal Disease equation) and drugs that influence uric acid and additionally for anxiety (in the association between SUA and depression) and depression (in the association between SUA and anxiety).

P_interaction = P value for sex-by-genotype interaction for its effect on psychiatric disorders.