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. 2013 Oct 29;8(10):e76143. doi: 10.1371/journal.pone.0076143

Table 3. Decomposition of TCA enzymes in structural domain according to scop fold classification.

Gene name/enzyme structural domain domain function label in the
(scop) Fig. 3
citA/citrate synthase a.103.1 Active site citA
citZ/citrate synthase a.103.1 Active site citZ
citB/aconitase c.83.1 Binding Iron-sulfur
c.8.2 Active site citB2
icd/isocitrate DH c.77.1 Active site icd
odhA/α–ketoglutarate A c.36.1 Binding TPP and Active site OdhA1
c.36.1 Binding TPP OdhA2
c.48.1 Active site OdhA3
odhB/α–ketoglutarate B b.84.1 Lipoyl binding OdhB1
a.9.1 pdhD binding OdhB2
c.43.1 Active site OdhB3
PdhD/enzyme 3 c.3.1 Binding FAD PdhD1
c.4.1 Binding NAD/FAD PdhD2
d.87.1 Active site PdhD3
SucC/Succinyl-CoA synthetase d.142.1 ATP graps SucC1
c.23.4 CoA Ligase SucC2
SucD/Succinyl-CoA synthetase c.2.1 CoA binding SucD1
c.23.4 active site SucD2
sdhA/succinate dehydrogenase c.3.1 FAD binding sdhA1
d.168.1 active site sdhA2
c.3.1 FAD/NAD(P)-binding domain sdhA3
a.7.3 Succinate dehydrogenase/ sdhA4
fumarate reductase flavoprotein C-terminal domain
sdhB/succinate dehydrogenase d.15.4 2Fe-2S ferredoxin-like sdhB1
a.1.2 alpha-helical ferredoxin sdhB2
sdhC/succinate dehydrogenase f.21.2 Fumarate reductase respiratory complex sdhC
transmembrane subunits
fumC/fumarase a.127.1 L-aspartase-like fumC1
a.127.1 fumC2
mdh/malate dehydrogenase c.2.1 binding site mdh1
d.162.1 active site mdh2
ywkA/malic enzyme c.58.1 active site ywkA1
c.2.1 NAD binding ywkA2
pyc/pyruvate carboxylase c.30.1 PreATP-grasp domain pyc1
d.142.1 Glutathione synthetase ATP-binding domain-like pyc2
b.84.2 Rudiment single hybrid motif pyc3
c.1.10 Aldolase pyc4
a.5.7 post-HMGL domain-like pyc5