Skip to main content
. 2013 Oct 29;8(10):e77497. doi: 10.1371/journal.pone.0077497

Figure 2. GLIPR-2 induces the EMT-like phenotype following enhanced migration and invasion of HepG2 cells via ERK1/2 activation.

Figure 2

(A) GLIPR-2 overexpession induced the EMT-like phenotype via ERK1/2 pathway. P-ERK1/2 was elevated in pCDNA3.0- GLIPR-2 transfected HepG2 cells but decreased gradually in dose-dependently manner of PD98059. E-cadherin decreased in pCDNA3.0- GLIPR-2 transfected HepG2 cells but increased gradually in dose-dependently manner of PD98059. Vimentin and α-smooth muscle actin increased in pCDNA3.0- GLIPR-2 transfected HepG2 cells but decreased gradually in dose-dependently manner of PD98059. (B) GLIPR-2 promotes cell migration and invasion via ERK1/2 activation. Data are presented as mean ± SD. *P<0.01 compared with the pcDNA3.0 group (black bar), ANOVA. # P<0.01 compared with the GLIPR-2 transfection group (grey bar), ANOVA.