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. 2013 Oct 29;8(10):e77497. doi: 10.1371/journal.pone.0077497

Figure 4. Suppression of ERK1/2 activation in human HCC cell attenuates EMT-like process following by migration and invasion induced by hypoxia.

Figure 4

(A) GLIPR-2, p-ERK1/2 and EMT markers expression in HepG2 cells after hypoxia 48 h or treated with 5,20 µM PD 98059. GLIPR-2 expression was elevated after hypoxia 48 h. (B) Hypoxia promotes HepG2 cells migration, invasion via ERK1/2 activation. Data are presented as mean ± SD. *P<0.01 compared with the normoxia group (black bar), ANOVA. # P<0.01 compared with the hypoxia group (grey bar), ANOVA.