. Author manuscript; available in PMC: 2014 Nov 1.

Published in final edited form as: Nucl Med Biol. 2013 Aug 15;40(8):10.1016/j.nucmedbio.2013.07.001. doi: 10.1016/j.nucmedbio.2013.07.001

Table 1.

Physiochemical properties and reported activities of orexin antagonists evaluated in this study.

	Compound	Molecular Weight	Log P^a (Log D^b)	^tPSA	K_i [nM]^c		IC₅₀ [nM]^c
					OX₁R	OX₂R	OX₁R	OX₂R
^*	CW3	391.46	3.33	54.37	165	12	243	25
^*	CW4	401.91	4.11 (2.16)	45.14	767	38	1600	215
^*	CW6	431.94	4.14	54.37	150	5	630	98

Calculated Log P

Measured Log D

See ref 13

Carbon-11 labeling position.