Table 1.

Characteristics of patients who received antithrombin concentrate

	Off-label (n=3914)	On-label (n=126)	Total (n=4040)
Age at Admission
Median (range)	56.5 days (1–6551)	79 days (1–6376)	57 days (1–6376)
≤30 days old	1789 (45.7)	58 (46.0)	1847 (45.7)
31–364 days old	845 (21.6)	19 (15.1)	864 (21.4)
1 – 2.9 years old	369 (9.4)	8 (6.4)	377 (9.3)
3 – 9.9 years old	463 (11.8)	13 (10.3)	476 (11.8)
10 – 17.9 years old	448 (11.5)	28 (22.2)	476 (11.8)
Sex
Female	1689 (43.2)	66 (52.4)	1755 (43.4)
Race/Ethnicity
White	1573 (40.2)	63 (50)	1636 (40.5)
Hispanic	728 (18.6)	22 (17.5)	750 (18.6)
Black	370 (9.5)	9 (7.1)	379 (9.4)
Other	425 (10.9)	9 (7.1)	434 (10.8)
Length of Stay
Median (range)	35 (1–585)	40.5(2–328)	35 (1–585)
0–14 days	722 (18.5)	18 (14.3)	740 (18.3)
15–30 days	1,018 (26)	34 (27)	1,052 (26)
31–60 days	1,063 (27.2)	36 (28.6)	1,099 (27.2)
61–90 days	478 (12.2)	19 (15)	497 (12.3)
>90 days	633 (16.2)	19 (15)	652 (16.1)
Mortality
In-hospital death	1190 (30.4)	27 (21.4)	1217 (30.1)
Number of days receiving AT per admission
Median (range)	2 (1–108)	3 (1–44)	2 (1–108)
1	1611 (41.2)	30 (23.8)	1641 (40.6)
2 – 3	1152 (29.4)	38 (30.2)	1190 (29.5)
4 – 5	467 (11.9)	17 (13.5)	484 (12)
>6	684 (17.5)	41 (32.5)	725 (18)
Top 5 Principal Diagnosis Categories
Congenital heart/lung defect	1433(36.6)	34 (27)	1467 (36.3)
Perinatal diseases	576 (14.7)	23 (18.3)	599 (14.8)
Circulatory disease	413 (10.6)	15 (11.9)	428 (10.6)
Congenital defect, non-heart/lung	292 (7.5)	13 (10.3)	305 (7.6)
Respiratory, incl pneumonia	292 (7.5)	2 (1.6)	294 (7.3)
Associated Diagnoses/Procedures
Sepsis	1322 (33.8)	35 (27.8)	1357 (33.6)
Chylothorax	294 (7.5)	25 (19.8)	319 (7.9)
Liver transplant	121 (3.1)	6 (4.8)	127 (3.1)
ECMO	1734 (44.3)	33 (26.2)	1767 (43.7)
Cardiopulmonary bypass	1459 (37.3)	28 (22.2)	1487 (36.8)
Hemorrhage and Thrombotic Events
Hemorrhage	1317 (33.7)	42 (33.3)	1359 (33.6)
Venous thrombosis	681 (17.4)	52 (41.3)	733 (18.1)
Arterial thrombosis	527 (13.5)	32 (25.4)	559 (13.8)
Any thrombosis	1109 (28.3)	72 (57.1)	1181 (29.2)