Table 2.

Baseline bone cross-sectional geometry, overall and by study arm: mean ± standard deviation relative to mean in normative sample.

Parameter*	All	p †	DHEA + COC Arm	Placebo Arm	p ‡
Femoral Shaft
n	73		40	33
Bone mineral density	95 ± 11	0.0001	96 ± 9	94 ± 13	0.58
Cross-sectional area	104 ± 13	0.005	106 ± 11	103 ± 15	0.26
Cortical thickness	51 ± 7	<0.0001	51 ± 6	50 ± 7	0.65
Inner diameter	146 ± 14	<0.0001	147 ± 14	144 ± 14	0.44
Outer diameter	110 ± 7	<0.0001	111 ± 7	109 ± 7	0.25
Buckling ratio	222 ± 38	<0.0001	221 ± 33	223 ± 44	0.84
Section modulus	114 ± 17	<0.0001	116 ± 16	110 ± 17	0.10
Bone strength index §	114 ± 17	<0.0001	117 ± 16	110 ± 17	0.10
Femoral Narrow Neck
n	76		42	34
Bone mineral density	92 ± 12	<0.0001	92 ± 12	93 ± 12	0.71
Cross-sectional area	95 ± 14	0.002	96 ± 14	93 ± 13	0.41
Cortical thickness	102 ± 17	0.25	102 ± 17	102 ± 16	0.92
Inner diameter	104 ± 9	0.0002	106 ± 8	102 ± 10	0.030
Outer diameter	102 ± 7	0.005	104 ± 7	100 ± 8	0.030
Buckling ratio	103 ± 20	0.17	106 ± 21	100 ± 18	0.21
Section modulus	90 ± 17	<0.0001	91 ± 18	88 ± 16	0.41
Bone strength index §	90 ± 17	<0.0001	92 ± 18	88 ± 16	0.41

^*Bone strength parameters are expressed as percentage of normal mean for age, height, and lean body mass, determined from an independent sample. Baseline DXA not available for 1 DHEA+COC subject and 2 placebo subjects.

^†Comparing mean to 100% of normal, by one-sample t-test.

^‡Comparing mean between treatment groups, by independent-sample t-test.

^§1000 × section modulus ÷ height.