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. Author manuscript; available in PMC: 2014 Oct 1.
Published in final edited form as: Stem Cells. 2013 Oct;31(10):10.1002/stem.1453. doi: 10.1002/stem.1453

Figure 5. Mouse ESC differentiation is affected by composition of ECM substrate.

Figure 5

Pluripotent mouse ESCs (CCE and R1) were cultured for up to 10 days on the indicated substrate in either neural progenitor (NP) or definitive endoderm (DE) differentiation medium. The fold-change in expression of neural progenitor (Pax6), mesoderm (Brachyury), definitive endoderm (Foxa2 and GATA4), and pluripotency (Oct4) markers were determined by quantitative PCR, relative to an initial population of pluripotent mouse ESCs at day 0 (mean ± standard error from 3 independent samples). * p < 0.05 as determined by ANOVA and is a comparison of gene expression on the culture substrates in the same induction medium.