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. Author manuscript; available in PMC: 2015 Jan 1.
Published in final edited form as: J Mech Behav Biomed Mater. 2013 Mar 15;29:10.1016/j.jmbbm.2013.03.003. doi: 10.1016/j.jmbbm.2013.03.003

Figure 4.3.

Figure 4.3

Glucose concentration at the center and surface of the engineered cartilage construct, over time in culture. Arrows indicate times when culture media is refreshed. The dashed line represents the critical threshold in glucose concentration necessary for proteoglycan synthesis. Simulations were performed in the open-source, customizable finite element program FEBio (www.febio.org) Maas et al. (2012).