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. Author manuscript; available in PMC: 2014 Nov 1.
Published in final edited form as: Crit Care Med. 2013 Nov;41(11):10.1097/CCM.0b013e31828cf436. doi: 10.1097/CCM.0b013e31828cf436

Figure 3. Calcium administration during sepsis induces liver injury and renal dysfunction via calcium/calmodulin-dependent protein kinase kinase (CaMKK) signaling.

Figure 3

C57Bl/6 and CaMKK−/− mice were subjected to cecal ligation and puncture, followed by normal saline (3 mL/100 gm) and imipenem/cilastatin (0.5 mg/kg) administration. After 12 hours, mice were administered CaCl2 (2.5 mg/kg) or equivolume normal saline by intraperitoneal injection. After 24 hours, mice were euthanized, and blood was isolated by cardiac puncture, and the serum analyzed for alanine aminotransferase (ALT) concentrations and blood urea nitrogen (BUN). (n=12 animals per group)