Table 3.
Crude and adjusted correlations between CAR and other cortisol features measured on the same day.
| Cortisol curve feature (label in Fig. 1) |
Unadjusted a |
Partially adjusted b |
Fully adjustedc |
|||
|---|---|---|---|---|---|---|
| Correlation (95% CI) | P-Value | Correlation (95% CI) | P-Value | Correlation (95% CI) | P-Value | |
| Wake up (A) | −0.55 (−0.58 to −0.51) | <0.0001 | −0.55 (−0.59 to −0.52) | <0.0001 | −0.56 (−0.60 to −0.53) | <0.0001 |
| Bedtime (H) | −0.08 (−0.12 to −0.03) | <0.01 | −0.07 (−0.12 to −0.02) | <0.01 | −0.07 (−0.11 to −0.02) | 0.006 |
| Early decline slope (C) |
−0.19 (−0.29, −0.10) | <0.0001 | −0.19 (−0.29, −0.10) | <0.0001 | −0.19 (−0.29, −0.09) | 0.0002 |
| Late decline slope (D) |
−0.06 (−0.10 to −0.01) | 0.01 | −0.06 (−0.11 to −0.02) | 0.01 | −0.06 (−0.11 to −0.02) | 0.006 |
| Total AUC (E + F + G) |
0.02 (−0.03 to 0.07) | 0.52 | 0.03 (−0.02 to 0.08) | 0.28 | 0.04 (−0.01 to 0.09) | 0.13 |
| CAR AUC (E) | −0.17 (−0.22 to −0.12) | <0.0001 | −0.18 (−0.23 to −0.13) | <0.0001 | −0.18 (−0.23 to −0.13) | <0.0001 |
| Early decline AUC (F) |
0.37 (0.33 to 0.41) | <0.0001 | 0.38 (0.33 to 0.42) | <0.0001 | 0.38 (0.34 to 0.43) | <0.0001 |
| Late decline AUC (G) |
−0.01 (−0.06 to 0.04) | 0.57 | 0.00 (−0.05 to 0.05) | 0.98 | 0.01 (−0.04 to 0.06) | 0.83 |
a
Only adjusted for wake up time.
b
Adjusted for wake up time, age, sex, race/ethnicity.
c
Partially adjusted + diabetes status, smoking, use of beta blockers, body mass index, income, education, Center for Epidemiological Studies Depression scale (CES-D) score.