Table 1.
Genotype and allele distributions of interleukin-6 tag single nucleotide polymorphisms in patients with chronic hepatitis B virus infection and those with self- limiting hepatitis B virus infection n (%)
| IL-6 SNP site | Chronic HBV infection | Self-limiting HBV infection | P value | OR (95%CI) |
| rs17147230 | n = 501 | n = 301 | ||
| AA | 155 (0.309) | 85 (0.282) | 1.0 | |
| AT | 241 (0.481) | 155 (0.515) | 0.348 | 0.853 (0.611-1.189) |
| TT | 105 (0.210) | 61 (0.203) | 0.784 | 0.944 (0.625-1.425) |
| A | 551 (0.550) | 325 (0.540) | 0.696 | 1.041 (0.850-1.276) |
| T | 451 (0.450) | 277 (0.460) | ||
| rs2066992 | ||||
| GG | 45 (0.090) | 20 (0.066) | 1.0 | |
| GT | 190 (0.379) | 118 (0.392) | 0.252 | 0.716 (0.403-1.271) |
| TT | 266 (0.531) | 163 (0.542) | 0.261 | 0.725 (0.414-1.272) |
| G | 280 (0.279) | 158 (0.262) | 0.460 | 1.090 (0.868-1.369) |
| T | 722 (0.721) | 444 (0.738) | ||
| rs2069837 | ||||
| AA | 331 (0.661) | 202 (0.671) | 1.0 | |
| AG | 151 (0.301) | 86 (0.286) | 0.670 | 1.072 (0.780-1.472) |
| GG | 19 (0.038) | 13 (0.043) | 0.758 | 0.892 (0.431-1.845) |
| A | 813 (0.811) | 490 (0.814) | 0.898 | 0.983 (0.759-1.274) |
| G | 189 (0.189) | 112 (0.186) | ||
| rs2069852 | ||||
| AA | 208 (0.415) | 138 (0.458) | 1.0 | |
| AG | 229 (0.457) | 132 (0.439) | 0.364 | 1.151 (0.850-1.559) |
| GG | 64 (0.128) | 31 (0.103) | 0.198 | 1.370 (0.848-2.213) |
| A | 645 (0.644) | 408 (0.678) | 0.165 | 0.859 (0.693-1.064) |
| G | 357 (0.356) | 194 (0.322) |
IL-6: Interleukin-6; HBV: Hepatitis B virus; SNP: Single nucleotide polymorphism.