Figure 5.

Potentiation in excised outside-out membrane patches. A, Baseline NMDAR channel activity (black trace) in 300 μm NMDA in an excised outside-out patch from a DIV2 hippocampal neuron was augmented following SGE-201 incubation for 60 s (0.2 μm, red trace). The patch was excised before drug applications. B, The all-points histograms represent 30 s of NMDA-induced channel activity before (black) and following (red) SGE-201 application from the patch represented in A. C, Summary of NPo analysis from eight excised outside-out patches.