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. 2013 Oct 30;33(44):17290–17300. doi: 10.1523/JNEUROSCI.2619-13.2013

Figure 8.

Figure 8.

Augmentation of LTP by 24(S)-HC. A, P120 hippocampal slices were challenged with a brief HFS that produces STP, but not LTP (open symbols). However, in the presence of SGE-201 the same stimulus effectively induced LTP (closed symbols). Responses in control slices were 91.9 ± 5.6% of baseline EPSP slope at 50% of maximum on the I/O curve, 60 min following HFS. With SGE-201 present, EPSP slopes were increased to 156 ± 10.8% of baseline (p < 0.001, N = 5 slices each). B, Similar experiment with 24(S)-HC. Black symbols represent effect of 1 μm 24(S)-HC (166.1 ± 19.4% of baseline; p < 0.001), whereas 0.1 μm 24(S)-HC did not significantly enhance LTP induction (103.9 ± 9.8% of baseline, p = n.s., N = 5 slices each). Insets for A and B show representative traces. Dashed lines are baseline and solid lines represent traces in the indicated oxysterol 60 min following HFS. Calibration bars: 1 mV, 5 ms.