Figure 2.

Following dMCAO, TK⁺ mice continued to receive GCV for 0, 3, 7, 14, or 28 d and were killed 28 d after stroke. A, Time lines of surgery, GCV treatment, and survival period. B, C, The numbers of EGFP-expressing (B) and DCX-expressing (C) cells in the septal hippocampus are inversely correlated with the duration of GCV treatment. Early withdrawal of GCV following dMCAO did not further significantly reduce the number of NPCs compared with mice that received GCV before stroke. However, groups that continued to receive GCV for 14 and 28 d, and significantly fewer type 1 NPCs remained in both the ipsilateral and contralateral DG. Type 2 NPCs were affected similarly. Significant statistical results are labeled above the bar of a specific duration when compared with the 0 d time point of each hemisphere. Additional significant statistics are indicated between time points. *p < 0.05; **p < 0.01; ***p < 0.005. N = 5–9/group.