Figure 7.

Conditional ablation of NPCs did not significantly affect the recovery of poststroke motor function. A–D, There was no significant difference in gait function perimeters (intensity, maximum contact area, and stance; A–C) or the extent of foot fault when traversing an elevated horizontal ladder (D) among TK⁺ stroke mice treated with GCV, TK⁺ stroke mice treated with vehicle, and TK⁻ mice stroke treated with GCV, compared with TK⁺ vehicle-treated, sham-operated mice. Regardless of genotype or treatment, stroke mice stepped through the ladder more often than the sham-operated mice. E, F, Representative photomicrographs showing the expression of EGFP (E) and DCX (F) in groups as indicated. G, There was a significant reduction in the type 1 NPCs in the SVZ in the TK⁺ mice treated with GCV compared with those treated with vehicle. Scale bars, 100 μm. Comparison with the sham group: *p < 0.05; **p < 0.01. N = 18–24/group.