Table II.
Flocculation conditions | mAb | Depth filter | Max ΔP (psi) | Capacity (L/m2) | Pool turbidity (NTU) | Sterile filter | Sterile filter capacity (L/m2) |
---|---|---|---|---|---|---|---|
Untreated | Mab-A | D0HC/X0HC | 22.0 | 70 | 1.35 | SHC | >10,000 |
0.1% SmP E, pH 7.0, 50 mM NaPi | Mab-A | 40MS | 11.8 | 261 | 1.19 | SHF | >10,000 |
0.1% SmP E, pH 7.0, 50 mM NaPi | Mab-A | 60HX | 4.9 | 254 | 1.91 | SHF | 8,900 |
0.2% SmP E, pH 7.0, 50 mM NaPi | Mab-A | 40MS | 9.8 | 319 | 1.54 | SHF | >10,000 |
0.2% SmP E, pH 7.0, 50 mM NaPi | Mab-A | 60HX | 10.1 | 329 | 1.22 | SHF | >10,000 |
0.2% SmP E, pH 6.5, 25 mM NaPi | Mab-T | 40MS | 20.0 | 385 | 2.11 | SHF | >10,000 |
0.2% SmP E, pH 6.51, 25 mM NaPi | Mab-T | 40MS | 12.0 | 588 | 2.25 | SHF | >10,000 |
0.4% SmP E, pH 7.01, 10 mM NaPi | Mab-T | 40MS | 20.0 | 294 | 2.35 | SHF | >10,000 |
0.2% SmP E, pH 6.5, 25 mM NaPi | Mab-T | 60HX | 20.0 | 327 | 2.96 | SHF | >10,000 |
0.2% SmP E, pH 6.51, 25 mM NaPi | Mab-T | 60HX | 20.0 | 310 | 3.32 | SHF | >10,000 |
0.4% SmP E, pH 7.01, 10 mM NaPi | Mab-T | 60HX | 20.0 | 310 | 3.25 | SHF | >10,000 |
Untagged SmP E.