Table 1.
Clinical and neuropsychological characteristics of the groups of aMCI patients who converted and did not convert to dementia
| Variables | Converted n 143 (68.8%) | Not converted n 65 (31.2%) | Significance (p) |
|---|---|---|---|
| Age (M±SD) | 73.9±7.9 | 72.7±8.1 | n.s. |
| Sex (F/M) | 89/54 | 35/30 | n.s. |
| Educational level, yrs (M±SD) | 7.4±3.7 | 7.7±3.5 | n.s. |
| Family history of dementia | 38 (26.6%) | 23 (35.4%) | n.s. |
| MMSE score (M±SD) | 25.4±1.5 | 26.1±1.7 | 0.005 |
| BPSDs (NPI score ≥4) | 72 (50.3%) | 28 (43.1%) | n.s. |
| NPI total score (M±SD) | 21.0±8.3 | 19.1±7.5 | n.s. |
| Depression (GDS score 11–16) | 57 (39.9%) | 30 (46.2%) | n.s. |
| GDS total score (M±SD) | 9.7±5.4 | 10.6±7.0 | n.s. |
| CT – SIVD | 68 (47.6%) | 22 (33.8%) | 0.04 |
| Temporal atrophy | 69 (48.3%) | 16 (24.6%) | 0.01 |
| Diabetes | 17 (11.9%) | 12 (18.5%) | n.s. |
| Hypertension | 81 (56.6%) | 39 (60%) | n.s. |
| Myocardial infarction | 16 (11.2%) | 11 (16.9%) | n.s. |
| Atrial fibrillation | 7 (4.9%) | 9 (13.8%) | 0.03 |
| Hypercholesterolemia | 55 (38.5%) | 21 (32.3%) | n.s. |
| Hypothyroidism | 17 (11.9%) | 12 (18.5%) | n.s. |
| B12/folate deficiency | 13 (9.1%) | 1 (1.5%) | 0.03 |
| RBD | 7 (4.9%) | 3 (4.6%) | n.s. |
| Mild parkinsonian signs | 7 (4.9%) | 0 | n.s. |
Abbreviations: BPSDs=behavioral and psychological symptoms of dementia; NPI=Neuropsychiatric Inventory; GDS=Geriatric Depression Scale; CT – SIVD=subcortical ischemic vascular disease, identified on CT scan; RBD=REM sleep behavior disorder