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. 2013 Oct 30;7:151. doi: 10.3389/fnbeh.2013.00151

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Copyright © 2013 Loos, Staal, Smit, De Vries and Spijker.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Stronger reinstatement of alcohol seeking in BXD16 mice. (A) Responding at the previously active lever decreased equally in both strains compared to the last FR1 session during extinction session, and (B) increased during the reinstatement session, with a stronger increase in BXD16 compared with C57BL/6J mice. (C) The preference for the active lever decreased during extinction compared with the last FR1 session, with no differences between strains and (D) increased during the reinstatement session compared with the last extinction session with no difference in this increase between strains. (E) Inactive lever responding did not decrease during extinction in comparison with the last FR1 session, but (F) significantly increase during the reinstatement session with no differences in this increase between strains. *P < 0.05, **P < 0.01.