Table 3.

Table 3A. Genes upregulated (4-fold or more) in gss mutant (Δgss) over wild type (gss+). In these tables data are the average of three independent experiments. "Annoted functions" are based on Ecogene and Affymetrix databases.
Pathways	Gene names	Annoted functions	Fold change
Arginine /polyamine metabolism
	carA	carbamoyl phosphate synthase small subunit	7.5
	carB	carbamoyl phosphate synthase large subunit	5.5
	puuD	gamma-glutamyl-gamma-aminobutyrate hydrolase	4.5
Purine metabolism
	purM	phosphoribosylaminoimidazolesynthetase	7.7
	purD	phosphoribosylglycinamidesynthetasephosphoribosylamine-glycine ligase	6.9
	purH	bifunctionalphosphoribosylaminoimidazolecarboxamideformyltransferase	5.8
	purL	phosphoribosylformyl-glycineamidesynthetase	5.6
	purK	phosphoribosylaminoimidazole carboxylase ATPase subunit	5.5
	purF	Amidophosphoribosyltransferase	4.3
	purE	phosphoribosylaminoimidazole carboxylase catalytic subunit	4.1
Sulfur utilization/succinate metabolism
	cysD	sulfateadenylyltransferase, subunit	8.2
	cysJ	sulfitereductase, subunit alpha	7.4
	cysP	Thiosulfate transporter subunit	6.4
	metF	5,10-methylenetetrahydrofolate reductase	5.1
	cysI	sulfitereductase, beta subunit	4.5
	astD	succinylglutamicsemialdehyde dehydrogenase	4.0
	sdhD	succinate dehydrogenase cytochrome b556, small membrane subunit	10.1
	sdhC	succinate dehydrogenase cytochrome b556, large membrane subunit	8.7
	sdhA	succinate dehydrogenase, flavoprotein subunit	6.2

Table 3B. Genes downregulated (−3 fold or more) in Δgss cells as compared to wild type (gss+) cells.
Gene names	Annoted functions	Fold- change
gss	bifunctional glutathionylspermidine amidase/glutathionylspermidine synthetase	−75.8
yghW	hypothetical protein	−10.8
modA	molybdate transporter periplasmic protein	−6.6
modB	molybdate ABC transporter permease protein	−6.0
nirC	nitrite transporter	−5.1
nirD	nitritereductase small subunit /// nitrite reductase, NAD(P)H-binding	−5.0
yjjW	predicted pyruvate formatelyase activating enzyme	−4.6
frdC	fumaratereductase subunit C (anaerobic)	−4.4
cusF	periplasmic copper-binding protein	−4.4
dcuC	C4-dicarboxylate transporter, (anaerobic)	−4.2
cusB	copper/silver efflux system membrane fusion protein	−3.7
modC	molybdate transporter ATP-binding protein	−3.7
adiY	putative ARAC-type regulatory protein	−3.6
hcr	HCP oxidoreductase, NADH-dependent	−3.6
hypC	hydrogenase assembly chaperone	−3.4
frdD	fumaratereductase subunit D (anaerobic)	−3.3
gldA	glycerol dehydrogenase, NAD	−3.2
frdB	fumaratereductase iron-sulfur subunit	−3.2
dcuB	anaerobic C4-dicarboxylate transporter, antiporter	−3.1
fumB	fumarase B /// fumaratehydratase class I, anaerobic	−3.0
narI	nitratereductase 1 gamma subunit	−3.0