Table 2.
MNP | Co (μg Fe/mL) | K (1/h) | T1/2 (h) | Vd (mL/kg) | CL (mL/h/kg) | AUC0-∞ (μg Fe·h/mL) |
---|---|---|---|---|---|---|
HP | 62.8 | 4.632 | 0.15 | 191.08 | 885.08 | 14 |
DNP | 108.9 | 0.055 | 12.60 | 110.19 | 6.06 | 1957 |
DNPH | 103.5 | 0.074 | 9.37 | 115.94 | 8.58 | 1490 |
Dose (20 g mouse) = 240 μg Fe. The parameters were defined as follow: Co, the initial plasma Fe content; C(t), the plasma Fe content at time “t”; K, the elimination rate constant; T1/2 (half-life), the time needed for 50% decrease of plasma Fe content; Vd, BW-normalized volume of distribution; CL, short for “clearance”; AUC0-∞, the total area-under-curve, indicating the total expected plasma MNP exposure per single dose.