. Author manuscript; available in PMC: 2014 Oct 7.

Published in final edited form as: Mol Pharm. 2013 Sep 11;10(10):10.1021/mp400360q. doi: 10.1021/mp400360q

Table 2.

Calculated parameters of MNP in blood circulation obtained from experimentally determined pharmacokinetic model.

MNP	Co (μg Fe/mL)	K (1/h)	T1/2 (h)	Vd (mL/kg)	CL (mL/h/kg)	AUC_0-∞ (μg Fe·h/mL)
HP	62.8	4.632	0.15	191.08	885.08	14
DNP	108.9	0.055	12.60	110.19	6.06	1957
DNPH	103.5	0.074	9.37	115.94	8.58	1490

Dose (20 g mouse) = 240 μg Fe. The parameters were defined as follow: C_o, the initial plasma Fe content; C(t), the plasma Fe content at time “t”; K, the elimination rate constant; T_1/2 (half-life), the time needed for 50% decrease of plasma Fe content; V_d, BW-normalized volume of distribution; CL, short for “clearance”; AUC_0-∞, the total area-under-curve, indicating the total expected plasma MNP exposure per single dose.